Determine how immune cells and inflammation shape the aging process in the brain to promote organ resilience during aging and in age-related diseases

Use protein engineering to specifically target immune cells and pathways in the old brain to improve brain function at the cellular, circuit and behavioral levels

Use antigen screening and T cell receptor sequences to determine what attracts T cells to aged organs

Establish the role of immune cells in rejuvenating interventions, is T cell rejuvenation necessary or sufficient to bring beneficial effects?